Biomolecular control

Biomolecular control for predictable performance

I’m interested in new circuit design guided by mathematical models to improve biomolecular control in bacterial cells. While many genetic parts and circuits have been made, there are still many elements that we still don’t understand when building more complex circuits. I believe by coupling well characterized circuits with modeling we can gain insights into how to improve circuits and how natural genetic circuits behave.

Adapted from “Control theory meets synthetic biology”

 

Relevant publications:

E. Yeung, A. J. Dy , K. B. Martin, A. H. Ng, D. Del Vecchio, J. L. Beck, J. J. Collins, and R. M. Murray. “The Effect of Compositional Context on Synthetic Gene Networks.” Cell Systems 5 (2017): 11–24 (pdf)

D. Del Vecchio, A. J. Dy , and Y. Qian. “Control theory meets synthetic biology.” Journal of The Royal Society Interface 13.120 (2016): 20160380. [review] (pdf)