In vitro diagnostics

In Vitro Diagnostics for Tracking Microbes and Viruses

I work to create new diagnostics using synthetic biology tools to enable detection of microbes like the bacterial present in the gut microbiome and the common viruses like HPV that cause cervical cancer.

 

Scheme for detecting DNA using isothermal amplification and cell-free expression.

Relevant publications:

J. S. Gootenberg*, O. O. Abudayyeh*, J. W. Lee, P. Essletzbichler, A. J. Dy , J. Joung, V. Verdine, N. Donghia, N. M. Daringer, C. A. Freije, C. Myhrvold, R. P. Bhattacharyya, J. Livny, A. Regev, E. V. Koonin, D. T. Hung, P. C. Sabeti, J. J. Collins, and F. Zhang. “Nucleic acid detection with CRISPR-Cas13a/C2c2.” Science 356.6336 (2017) 438-442. (pdf)